CITALOPRAM HYDROBROMIDE

CITALOPRAM HYDROBROMIDE

PRODUCT IDENTIFICATION

CAS NO.

59729-33-8 (Base)

CITALOPRAM HYDROBROMIDE

EINECS NO.

261-891-1

FORMULA

C₂₀H₂₁FN₂O·HBr

MOL WT.

405.35

H.S. CODE

TOXICITY

SYNONYMS

Celexa^TM;

(±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3- dihydroisobenzofuran- 5-carbonitrile, hydrobromide; 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro- 5- isobenzofuran carbonitrile hydrobromide;

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT

180 - 187 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

SOLVENT SOLUBILITY

5.4 - 6.4

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

APPLICATIONS

Citalopram is a highly selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI) with minimal effects on the neuronal reuptake of norepinephrine and dopamine. It is a bicyclic phthalane derivative (racemic) which is not related to the tricyclic or tetracyclic antidepressants. It used in the treatment of major depressive disorder. The hydrobromide salt of it is administered orally. Chemically, it is (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3- dihydroisobenzofuran- 5-carbonitrile, hydrobromide. Citalopram hydrobromide is a white to off-white powder; sparingly soluble in water and soluble in ethanol.

SSRIs are used to treat depressions and effective for obsessive-compulsive disorder, posttraumatic stress disorder, premenstrual dysphoric mood disorder, panic disorder, generalized anxiety disorder, and bulimia. Drugs used to treat depressions include;

TRICYCLIC ANTIDEPRESSANTS

Amitriptyline [CAS #: 50-48-6, 549-18-8 (HCl)]

Amoxapine [CAS #: 14028-44-5]

Clomipramine [CAS #: 303-49-1]

Desipramine [CAS #: 50-47-5 58-28-6 (HCl)]

Doxepin [CAS #: 1668-19-5, 1229-29-4 (HCl)]
Imipramine [CAS #: 50-49-7, 113-52-0 (HCl)]
Nortriptyline [CAS #: 894-71-3 (HCl)]
Protriptyline [CAS #: 438-60-8, 1225-55-4(HCl)]
Trimipramine [CAS #: 739-71-9, 521-78-8 (Maleate)]

TETRACYCLIC ANTIDEPRESSANT
- Maprotiline [CAS #: 10262-69-8, 10347-81-6 (HCl)]

MONOAMINE OXIDASE INHIBITORS
- Isocarboxazid [CAS #: 59-63-2, 24631-64-9 (Sulfate)]
- Phenelzine [CAS #: 51-71-8, 156-51-4 (Sulfate)]
- Tranylcypromine [CAS #: 155-09-9]

SELECTIVE SEROTONIN REUPTAKE INHIBITORS
- Fluoxetine [CAS #: 54910-89-3, 59333-67-4 (HCl)]
- Paroxetine [CAS #: 61869-08-7]
- Sertraline [CAS #: 79617-96-2, 79559-97-0 (HCl)]
- Escitalopram Oxalate [CAS #: 128196-01-0]
- Citalopram [CAS #: 59729-33-8, 59729-33-8 (HBr)]
- Fluvoxamine [CAS #: 54739-18-3, 6387-89-9 (Maleate)]

SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR
- Duloxetine [CAS #: 116539-59-4]

PSYCHOSTIMULANTS

Dextroamphetamine [CAS #: 51-64-9, 51-63-8 (Sulfate)]
Methylphenidate [CAS #: 113-45-1, 298-59-9 (HCl)]

MODIFIED ANTIDEPRESSANTS
- Trazodone [CAS #: 19794-93-5, 25332-39-2 (HCl)]
- Venlafaxine [CAS #: 93413-69-5, 99300-78-4 (HCl)]
- Nefazodone [CAS #: 83366-66-9]
- Mirtazapine [CAS #: 61337-67-5]
- Bupropion [CAS #: 31677-93-7]
- Buspirone [CAS #: 36505-84-7]
- Reboxetine [CAS #: 71620-89-8]

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

99.0% min

MELTING POINT

180 - 187 C

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

10ppm max

INDIVIDUAL IMPURITY

0.5% max

LOSS ON DRYING

0.5% max

TRANSPORTATION

PACKING

25kgs in fiber drum

HAZARD CLASS

UN NO.

PRICES